Many medications and drug therapies actually cause damage to the vessel wall – the endothelial layer (which in turn is only one cell layer thick) is the prime area that is predisposed to injury during exposure to the administered medication – here are the latest from the Infusion Nurses Society in regards to non-cytotoxic vesicant and irritant medication administration. Be mindful that many of these medications CANNOT be administered via a peripheral device, which includes midline catheters..

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Development of an Evidence-Based List of Noncytotoxic Vesicant Medications and Solutions